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Additional information about the drug Omeprazole

Omeprazole 20mg – “Omeprazole Sodium Bicarbonate Capsules, Zegerid” “Duodenal Ulcer, Gastric Ulcers, Gastroesophageal Reflux Disease, GERD, Erosive Esophagitis, Zollinger-Ellison Syndrome”
Prilosec 20mg 40mg – “Omeprazole, Antra, Losec, Omez, Protoloc” “Duodenal Ulcer, Gastric Ulcers, Gastroesophageal Reflux Disease, GERD, Erosive Esophagitis, Zollinger-Ellison Syndrome”

Omeprazole is both an over-the-counter and a prescription medication. The over-the-counter form is used to treat heartburn. The prescription form is used to treat gastroesophageal reflux disease (GERD), certain ulcers, Zollinger-Ellison Syndrome, erosive esophagitis (EE), and infections cause by the bacteria H. pylori. This medication page refers to the prescription form of omeprazole.
Omeprazole belongs to a group of drugs called proton-pump inhibitors, which work by reducing the amount of acid made in the stomach.
This medication comes in delayed capsule form and in packets to be mixed with water to form a liquid (suspension). It is taken once or twice daily, one hour before a meal.
Common side effects of omeprazole include constipation, gas, nausea, vomiting, and headache.
Omeprazole can cause dizziness, drowsiness, and blurred vision. Do not drive or operate heavy machinery until you know how omeprazole affects you.
CYP2C19 is an enzyme in the blood that is responsible for breaking down omeprazole and other drugs in the body. Some patients have less of this protein in their bodies, affecting how much of the drug gets eliminated. Levels of CYP2C19 can vary greatly between individuals, and those having less of this protein are known as “poor metabolizers.” 
CD20 positive cells were present in clusters in 58% of all omeprazole-induced AIN patients and 37% of vasculitis patients.

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  • For Period 2, 120 mL water was also given at one half hour prior to initiating the meal.This allows the omeprazole and antacid formulation to be administered in close proximity to meals that often induce or are associated with gastric acid-related symptoms. This trial assessed pharmacokinetics and gastric acidity under these conditions, indicating that omeprazole plus antacid combination may be useful for treating meal-induced or meal-associated heartburn. Each healthy volunteer subject received an oral antacid formulation with omeprazole; omeprazole powder alone; Prilosec capsule (US formulation); and Nexium capsule (US formulation) in each period.Immediately thereafter, subjects were given one chewable antacid tablet, which they began chewing.
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